反应详情

Methyl 2-[1-[4-(2-naphthamido)benzyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]acetate (60 mg, 0.13 mmol) and lithium hydroxide monohydrate (10 mg, 0.24 mmol) were added into a mixed solution of tetrahydrofuran (5 mL) and water (20 mL), and reacted at room temperature for 2 hours. Tetrahydrofuran was rotate evaporated. The pH was adjusted to 3 with 1 mol/L hydrochloric acid. It was extracted with ethyl acetate, and dried over anhydrous sodium sulfate. The organic phase was rotate evaporated to dryness to obtain a light brown solid 28 mg, at a yield of 49.3%.

1. customreacted at room temperature for 2 hours
2. extractionIt was extracted with ethyl acetate
3. dry with materialdried over anhydrous sodium sulfate
4. customThe organic phase was rotate evaporated to dryness