HRID589494

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20496286

未命名化合物

HCID86730985

未命名化合物

结构：CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(N)c4)ncnc3[nH]2)CC1

HCID86730986

1(2H)-Pyridinecarboxamide, 4-[4-(3-amino-4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-N,N-dimethyl-

C20H21FN6O

结构：CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(NC(=O)c5ccc(C(C)(C)O)cc5F)c4C(O[SiH2]C(C)(C)C)(c4ccccc4)c4ccccc4)ncnc3[nH]2)CC1

HCID131734464

未命名化合物

PRODUCTS

生成物

结构：CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(NC(=O)c5ccc(C(C)(C)CO)cc5)c4)ncnc3[nH]2)CC1

HCID71231460

未命名化合物

PROCEDURE

实验过程

Example 21 was prepared analogue to Intermediate 9 by replacing Intermediate 7 with Intermediate 10 and Intermediate 8 with 4-(2-hydroxy-1,1-dimethyl-ethyl)-benzoic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c65cb3e26dc24013b56b13a60fab5a7a
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233111B2
来源说明: uspto-grants-2016_01

反应 SMILES

CN(C)C(N1CC=C(C2NC3N=CN=C(C4C=CC=C(NC(=O)C5C=CC(C(O)(C)C)=CC=5F)C=4C(C4C=CC=CC=4)(C4C=CC=CC=4)O[SiH2]C(C)(C)C)C=3C=2)CC1)=O.[CH3:60][N:61]([CH3:87])[C:62]([N:64]1[CH2:69][CH:68]=[C:67]([C:70]2[NH:86][C:73]3[N:74]=[CH:75][N:76]=[C:77]([C:78]4[CH:83]=[CH:82][C:81]([F:84])=[C:80]([NH2:85])[CH:79]=4)[C:72]=3[CH:71]=2)[CH2:66][CH2:65]1)=[O:63].FC1C=C(C(O)(C)C)C=CC=1C(O)=O.[OH:102][CH2:103][C:104]([C:107]1[CH:115]=[CH:114][C:110]([C:111](O)=[O:112])=[CH:109][CH:108]=1)([CH3:106])[CH3:105]>>[CH3:60][N:61]([CH3:87])[C:62]([N:64]1[CH2:65][CH:66]=[C:67]([C:70]2[NH:86][C:73]3[N:74]=[CH:75][N:76]=[C:77]([C:78]4[CH:83]=[CH:82][C:81]([F:84])=[C:80]([NH:85][C:111](=[O:112])[C:110]5[CH:114]=[CH:115][C:107]([C:104]([CH3:105])([CH3:106])[CH2:103][OH:102])=[CH:108][CH:109]=5)[CH:79]=4)[C:72]=3[CH:71]=2)[CH2:68][CH2:69]1)=[O:63]