HRID589496

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(N)cc(F)cc1-c1ncnc2[nH]c(C3=CCOCC3)cc12

HCID86730987

未命名化合物

结构：CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(NC(=O)c5ccc(C(C)(C)O)cc5F)c4C(O[SiH2]C(C)(C)C)(c4ccccc4)c4ccccc4)ncnc3[nH]2)CC1

HCID131734464

未命名化合物

PRODUCTS

生成物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)O)cc2F)cc(F)cc1-c1ncnc2[nH]c(C3=CCOCC3)cc12

HCID71230655

未命名化合物

PROCEDURE

实验过程

Example 22 was prepared analogue to Intermediate 9 by replacing Intermediate 7 with Intermediate 12.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0341c96de59546e88ad4eb77fc61f2b9
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233111B2
来源说明: uspto-grants-2016_01

反应 SMILES

CN(C)C(N1CC=C(C2NC3N=CN=C(C4C=CC=C(N[C:26](=[O:38])[C:27]5[CH:32]=[CH:31][C:30]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:29][C:28]=5[F:37])C=4C(C4C=CC=CC=4)(C4C=CC=CC=4)O[SiH2]C(C)(C)C)C=3C=2)CC1)=O.[O:60]1[CH2:65][CH:64]=[C:63]([C:66]2[NH:83][C:69]3[N:70]=[CH:71][N:72]=[C:73]([C:74]4[C:75]([CH3:82])=[C:76]([NH2:81])[CH:77]=[C:78]([F:80])[CH:79]=4)[C:68]=3[CH:67]=2)[CH2:62][CH2:61]1>>[O:60]1[CH2:61][CH:62]=[C:63]([C:66]2[NH:83][C:69]3[N:70]=[CH:71][N:72]=[C:73]([C:74]4[C:75]([CH3:82])=[C:76]([NH:81][C:26](=[O:38])[C:27]5[CH:32]=[CH:31][C:30]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:29][C:28]=5[F:37])[CH:77]=[C:78]([F:80])[CH:79]=4)[C:68]=3[CH:67]=2)[CH2:64][CH2:65]1