4-[4-(3-Amino-5-fluoro-2-methyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid dimethylamide → 3-[6-(3,6-Dihydro-2H-thiopyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-5-fluoro-2-methyl-phenylamine
Reaction equation
CN(C)C(N1[CH2:10][CH:9]=[C:8]([C:11]2[NH:28][C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([NH2:26])[C:20]=4[CH3:27])[C:13]=3[CH:12]=2)[CH2:7][CH2:6]1)=O.ClC1C2C=C(C3CC[S:43]CC=3)NC=2N=CN=1>>[S:43]1[CH2:10][CH:9]=[C:8]([C:11]2[NH:28][C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[C:20]([CH3:27])=[C:21]([NH2:26])[CH:22]=[C:23]([F:25])[CH:24]=4)[C:13]=3[CH:12]=2)[CH2:7][CH2:6]1Participants
3
Reactant 2
Product 1
Procedure
Intermediate 16 was prepared analogue to Intermediate 6 by replacing Intermediate 3 with Intermediate 15.
Sources & evidence
- ORD record
- ord-09b4f88c8d7d4ef29eb5728fca1b3a89
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09233111B2
Reaction notes
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