HRID589501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74372

Benzoyl chloride, 4-(1,1-dimethylethyl)-

C11H13ClO

HCID4400782

4-(Dimethylamino)benzoyl chloride

C9H10ClNO

结构：Cc1c(N)cc(F)cc1-c1ncnc2[nH]c(C3=CCC4(CC3)OCCO4)cc12

HCID86730993

未命名化合物

PRODUCTS

生成物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCC4(CC3)OCCO4)cc12

HCID71231462

未命名化合物

PROCEDURE

实验过程

Example 27 was prepared analogue to Example 15 by replacing Intermediate 6 with Intermediate 18 and 4-dimethyaminobenzoyl chloride with 4-tert-butylbenzoyl chloride.

WORKUP

后处理

customExample 27 was prepared analogue to Example 15

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bff16d0bb7f74e7d919d19972903471b
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233111B2
来源说明: uspto-grants-2016_01

反应 SMILES

[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[NH:28][C:14]4[N:15]=[CH:16][N:17]=[C:18]([C:19]5[C:20]([CH3:27])=[C:21]([NH2:26])[CH:22]=[C:23]([F:25])[CH:24]=5)[C:13]=4[CH:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.CN(C)C1C=CC(C(Cl)=O)=CC=1.[C:41]([C:45]1[CH:53]=[CH:52][C:48]([C:49](Cl)=[O:50])=[CH:47][CH:46]=1)([CH3:44])([CH3:43])[CH3:42]>>[C:41]([C:45]1[CH:46]=[CH:47][C:48]([C:49]([NH:26][C:21]2[CH:22]=[C:23]([F:25])[CH:24]=[C:19]([C:18]3[C:13]4[CH:12]=[C:11]([C:8]5[CH2:9][CH2:10][C:5]6([O:1][CH2:2][CH2:3][O:4]6)[CH2:6][CH:7]=5)[NH:28][C:14]=4[N:15]=[CH:16][N:17]=3)[C:20]=2[CH3:27])=[O:50])=[CH:52][CH:53]=1)([CH3:44])([CH3:42])[CH3:43]