4-Cyclopropyl-N-{5-fluoro-2-methyl-3-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenyl}-benzamide → N-{5-Fluoro-2-methyl-3-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenyl}-4-(pentafluoro-sulfanyl)-benzamide

HRID 589505Notes

Reaction equation

HRID 589505 reaction equation
C1(C2C=CC(C(NC3C=C(F)C=C(C4C5C=C(C6CCNCC=6)NC=5N=CN=4)C=3C)=O)=CC=2)CC1.C(OC([N:43]1[CH2:48][CH:47]=[C:46]([C:49]2[NH:80][C:52]3[N:53]=[CH:54][N:55]=[C:56]([C:57]4[CH:62]=[C:61]([F:63])[CH:60]=[C:59]([NH:64][C:65](=[O:78])[C:66]5[CH:71]=[CH:70][C:69]([S:72]([F:77])([F:76])([F:75])([F:74])[F:73])=[CH:68][CH:67]=5)[C:58]=4[CH3:79])[C:51]=3[CH:50]=2)[CH2:45][CH2:44]1)=O)(C)(C)C>>[F:63][C:61]1[CH:62]=[C:57]([C:56]2[C:51]3[CH:50]=[C:49]([C:46]4[CH2:47][CH2:48][NH:43][CH2:44][CH:45]=4)[NH:80][C:52]=3[N:53]=[CH:54][N:55]=2)[C:58]([CH3:79])=[C:59]([NH:64][C:65](=[O:78])[C:66]2[CH:71]=[CH:70][C:69]([S:72]([F:77])([F:73])([F:74])([F:75])[F:76])=[CH:68][CH:67]=2)[CH:60]=1

Participants

3

Reactant 2

HCID 712314394-Cyclopropyl-N-{5-fluoro-2-methyl-3-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenyl}-benzamideHCID 867309974-(4-{5-Fluoro-2-methyl-3-[4-(pentafluoro-sulfanyl)-benzoylamino]-phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Product 1

HCID 86730998N-{5-Fluoro-2-methyl-3-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenyl}-4-(pentafluoro-sulfanyl)-benzamide

Procedure

Intermediate 24 was prepared analogue to Intermediate 22 by replacing Intermediate 21 with Intermediate 23.

Sources & evidence

ORD record
ord-e9c03ec592d2464b970760e6d60cea0d
Source dataset
uspto-grants-2016_01
Patent number
US09233111B2

Reaction notes

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