4-tert-Butylbenzoyl chloride → N-(3-Bromo-5-fluoro-2-methyl-phenyl)-4-tert-butyl-benzamide

HRID 589509Notes

Reaction equation

HRID 589509 reaction equation
COC(=O)C1C=CC(C([NH:10][C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([Br:18])[C:12]=2[CH3:19])=O)=C(F)C=1.[C:24]([C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>>[Br:18][C:13]1[C:12]([CH3:19])=[C:11]([NH:10][C:32](=[O:33])[C:31]2[CH:35]=[CH:36][C:28]([C:24]([CH3:27])([CH3:26])[CH3:25])=[CH:29][CH:30]=2)[CH:16]=[C:15]([F:17])[CH:14]=1

Participants

3

Reactant 2

HCID 743724-tert-Butylbenzoyl chlorideHCID 71230752N-(3-Bromo-5-fluoro-2-methyl-phenyl)-3-fluoro-terephthalamic acid methyl ester

Product 1

HCID 71230679N-(3-Bromo-5-fluoro-2-methyl-phenyl)-4-tert-butyl-benzamide

Procedure

Intermediate 37 was prepared analogue to Intermediate 34 by replacing Intermediate 33 with 4-tert-butyl-benzoyl chloride.

Sources & evidence

ORD record
ord-2d56716f9d424197bccce699fa2d2f97
Source dataset
uspto-grants-2016_01
Patent number
US09233111B2

Reaction notes

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