4-(Dimethylamino)benzoyl chloride → N-(3-Bromo-5-fluoro-2-methyl-phenyl)-4-dimethylamino-benzamide

HRID 589515Notes

Reaction equation

HRID 589515 reaction equation
COC(=O)[C:4]1[CH:21]=[CH:20][C:7]([C:8]([NH:10][C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([Br:18])[C:12]=2[CH3:19])=[O:9])=[C:6](F)[CH:5]=1.[CH3:24][N:25](C)[C:26]1C=CC(C(Cl)=O)=CC=1>>[Br:18][C:13]1[C:12]([CH3:19])=[C:11]([NH:10][C:8](=[O:9])[C:7]2[CH:20]=[CH:21][C:4]([N:25]([CH3:26])[CH3:24])=[CH:5][CH:6]=2)[CH:16]=[C:15]([F:17])[CH:14]=1

Participants

3

Reactant 2

HCID 44007824-(Dimethylamino)benzoyl chlorideHCID 71230752N-(3-Bromo-5-fluoro-2-methyl-phenyl)-3-fluoro-terephthalamic acid methyl ester

Product 1

HCID 71230977N-(3-Bromo-5-fluoro-2-methyl-phenyl)-4-dimethylamino-benzamide

Procedure

Intermediate 46 was prepared analogue to Intermediate 34 by replacing Intermediate 33 with 4-dimethylamino-benzoyl chloride.

Sources & evidence

ORD record
ord-cc6fb26de4ee4d668e6a7b28139b041a
Source dataset
uspto-grants-2016_01
Patent number
US09233111B2

Reaction notes

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