Water → HCID 71230933, compound

Participants

Reaction Steps

To a solution of Intermediate 49 (80 mg, 0.162 mmol) in MeOH/DCM (1:1) were added cerium(III) chloride heptahydrate (66.3 mg, 0.178 mmol) and NaBH4 (6.1 mg, 0.162 mmol). The resulting mixture was stirred at r.t. for 2 hrs. Water was added, and the mixture was extracted three times with DCM/isopropanol (3:1). The combined organic layers were dried, filtered, and evaporated to dryness. The resulting residue was purified using flash chromatography (silica gel, EtOAc/MeOH/N H3 gradient) to yield Example 55.

Provenance & Evidence