HuagongsheHuagongshe Chemistry Print Report · For research reference only
7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- → 4-tert-Butyl-N-[2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenyl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| Reactant | 4-(4-{2-Hydroxymethyl-3-[6-(1-hydroxy-1-methyl-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid dimethylamide | HCID 71230822 | — |
| Reactant | 4-[4-(3-Amino-5-fluoro-2-methyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid dimethylamide | HCID 86730983 | — |
| Product | 4-tert-Butyl-N-[2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenyl]-benzamide | HCID 71231453 | — |
Reaction Steps
Intermediate 51 was prepared analogue to Intermediate 6 by replacing Intermediate 3 with 6-chloro-7-deazapurine and Intermediate 5 with Intermediate 48.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233111B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-c7b4c8a2765f4373b32c7902484855ee |
| Source note | uspto-grants-2016_01 |