HRID589524

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ncnc2[nH]c(Br)cc12

HCID71231463

未命名化合物

结构：Clc1ncnc2[nH]c(C3=CCC4(CC3)OCCO4)cc12

HCID86730994

未命名化合物

PRODUCTS

生成物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ncnc2[nH]c(C3=CCC4(CC3)OCCO4)cc12

HCID71231448

未命名化合物

PROCEDURE

实验过程

Example 65 was prepared analogue to Intermediate 17 by replacing 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine with Intermediate 54.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eee9b561dcb249289ad5099b10ba7b2d
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233111B2
来源说明: uspto-grants-2016_01

反应 SMILES

Cl[C:2]1[C:3]2[CH:10]=[C:9]([C:11]3[CH2:20][CH2:19][C:14]4([O:18][CH2:17][CH2:16][O:15]4)[CH2:13][CH:12]=3)[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.BrC1NC2N=CN=C([C:30]3[C:31]([CH3:49])=[C:32]([NH:36][C:37](=[O:48])[C:38]4[CH:43]=[CH:42][C:41]([C:44]([CH3:47])([CH3:46])[CH3:45])=[CH:40][CH:39]=4)[CH:33]=[CH:34][CH:35]=3)C=2C=1>>[C:44]([C:41]1[CH:42]=[CH:43][C:38]([C:37]([NH:36][C:32]2[CH:33]=[CH:34][CH:35]=[C:30]([C:2]3[C:3]4[CH:10]=[C:9]([C:11]5[CH2:20][CH2:19][C:14]6([O:18][CH2:17][CH2:16][O:15]6)[CH2:13][CH:12]=5)[NH:8][C:4]=4[N:5]=[CH:6][N:7]=3)[C:31]=2[CH3:49])=[O:48])=[CH:39][CH:40]=1)([CH3:47])([CH3:45])[CH3:46]