反应详情

温度

155 °C

Pyridine hydrochloride (23 gm) was added to 4-(4-methoxypyrimidin-2-ylamino)benzonitrile (15 gm) and then heated to 150 to 160° C. for 3 hours. The mixture was then cooled to room temperature, then transferred into ice water and stirred for 1 hour. The resulting precipitate was filtered and washed with water. The solid thus obtained was slurried in acetonitrile at 0 to 5° C. for 1 hour and filtered. The solid obtained was dried to give 12.3 gm of 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile.

1. temperatureThe mixture was then cooled to room temperature
2. filtrationThe resulting precipitate was filtered
3. washwashed with water
4. customThe solid thus obtained
5. filtrationfiltered
6. customThe solid obtained
7. customwas dried