Methyl triflate → 1-Methyl-3-(piperidine-1-sulfonyl)-3h-imidazol-1-ium triflate salt

HRID 589596Notes

Reaction equation

HRID 589596 reaction equation
[N:1]1([S:6]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)(=[O:8])=[O:7])[CH:5]=[CH:4][N:3]=[CH:2]1.[O:15](C)[S:16]([C:19]([F:22])([F:21])[F:20])(=[O:18])=[O:17]>C(Cl)Cl>[O-:18][S:16]([C:19]([F:22])([F:21])[F:20])(=[O:17])=[O:15].[CH3:19][N+:3]1[CH:4]=[CH:5][N:1]([S:6]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)(=[O:8])=[O:7])[CH:2]=1

Participants

4

Reactant 2

HCID 9526Methyl triflateHCID 29901621-(Imidazole-1-sulfonyl)-piperidine

Product 1

HCID 873994191-Methyl-3-(piperidine-1-sulfonyl)-3h-imidazol-1-ium triflate salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 1-H (79.6 mg, 0.37 mmol) in CH2Cl2 (2 mL), cooled to 0° C., was added methyl triflate (46 μL, 0.407 mmol). The reaction mixture was allowed to warm to ambient temperature and stirred for 3 hours. The solvent was evaporated under reduced pressure to afford compound 1-I as a white solid. MS (method 2): m/z 229.9 (MH+).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-ffb3becf09e945958c57bf3c657a3935
Source dataset
uspto-grants-2016_01
Patent number
US09233947B2

Reaction notes

Loading…