HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 589620Generated: October 31, 2026
Ammonia → 2-Amino-6-methylisonicotinic acid
https://huagongshe.com/reaction/589620
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Sodium Sulfide | HCID 14804 | — |
| Reactant | 2-Chloro-6-methylpyridine-4-carboxylic acid | HCID 141209 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Amino-6-methylisonicotinic acid | HCID 12404027 | — |
Reaction Steps
2-chloro-6-methylisonicotinic acid (9 g), of aq ammonia (44 ml), of Cu(II)SO4 (0.9 g) and of sodium sulphide (0.32 g) are added to an autoclave and heated to 155° C. overnight. The crude product is suspended in water to yield 2-amino-6-methylisonicotinic acid (3.6 g). HPLC: Rt=0.37 min (method D)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09233950B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-c2d7493784304a61aa83ce6098fd2189 |
|---|
| Source note | uspto-grants-2016_01 |
|---|
