HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 589660Generated: October 31, 2026
Phosphorus oxychloride → 7-Chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride
https://huagongshe.com/reaction/589660
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 86689183 | HCID 86689183 | — |
| Product | 7-Chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride | HCID 58713149 | 61% |
Reaction Steps
A mixture of potassium 7-chloro-3-methylbenzothiophene-2-sulfonate (100 mg, 0.34 mmol) in POCl3 (5 mL) was heated at 60° C. over night. The POCl3 was evaporated and the crude product was purified on a small amount of silica using CH2Cl2 as eluent to give 58 mg of the title compound (61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09233946B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-f2fe468142fb4c7b92ba67d9be2e2c4e |
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| Source note | uspto-grants-2016_01 |
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