HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 589662Generated: November 1, 2026
Phosphorus oxychloride → 5-Methoxy-3-methylbenzothiophene-2-sulfonyl chloride
https://huagongshe.com/reaction/589662
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 86689185 | HCID 86689185 | — |
| Product | 5-Methoxy-3-methylbenzothiophene-2-sulfonyl chloride | HCID 57440339 | 90% |
Reaction Steps
A mixture of potassium 5-methoxy-3-methylbenzothiophene-2-sulfonate (100 mg, 0.34 mmol) in POCl3 (5 mL) was heated at 60° C. over night. The POCl3 was evaporated and the remaining crude product was purified on a small amount of silica using CH2Cl2 as eluent to give 80 mg of the title compound (90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09233946B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-0743abe4fe2b4950a6d5cfedb70a8a31 |
|---|
| Source note | uspto-grants-2016_01 |
|---|
