참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 3-Methylbenzothiophene-2-sulfonic acid | HCID 86689187 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methyl-1-benzothiophene-2-sulfonyl chloride | HCID 2736815 | 115.5% |
반응 단계
The 3-methylbenzothiophene-2-sulfonic acid (45 mg, 0.20 mmol) was mixed with POCl3 (2 mL, 20 mmol) and CH2Cl2 (2 mL) and heated at 70° C. for 6 h. The reaction mixture was diluted with CH2Cl2 before the reaction was quenched with ice and stirred at room temperature for 1 h. The organic phase was separated. Evaporation of the solvents afforded 57 mg the title compound (91%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09233946B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_01 |
|---|
| ORD ID | ord-5eace7e6e0c54f7e88593a3fa6d9adeb |
|---|
| 출처 메모 | uspto-grants-2016_01 |
|---|
