HCID 86689188, compound → HCID 178431996, compound

HRID 589683Notes

Reaction equation

HRID 589683 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([S:12](Cl)(=[O:14])=[O:13])=[C:9]([CH3:16])[C:8]=2[CH:17]=1)([CH3:3])[CH3:2].[NH2:18][C:19]1[CH:20]=[C:21]([C:25]2[NH:29][N:28]=[N:27][N:26]=2)[CH:22]=[CH:23][CH:24]=1>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([S:12]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]4[NH:29][N:28]=[N:27][N:26]=4)[CH:20]=3)(=[O:14])=[O:13])=[C:9]([CH3:16])[C:8]=2[CH:17]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 86689188HCID 86689188, compound2×HCID 178507542HCID 178507542, compound

Product 1

HCID 178431996HCID 178431996, compoundYield 21.5%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-isopropyl-3-methylbenzofuran-2-sulfonyl chloride (Intermediate 16) (24 mg, 0.09 mmol) and 5-(3-amino-phenyl)tetrazole (28 mg, 0.17 mmol) giving 7.7 mg (21%) of the title compound. MS (ESI+) calcd for C19H19N5O3S 397.12086, found 397.12046.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-ed2b41861f2e490686676ff724a79777
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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