2-Methoxyphenylboronic acid → HCID 178489300, compound

HRID 589693Notes

Reaction equation

HRID 589693 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1B(O)O>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 178527479HCID 178527479, compound2×

Product 1

HCID 178489300HCID 178489300, compoundYield 28%

Procedure

The product was prepared according to General Procedure 3, described in Example 22, starting from 5-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide (Intermediate 17) (19 mg, 0.05 mmol) and 2-methoxyphenylboronic acid (9 mg, 0.06 mmol) giving 5.7 mg (28%) of the title compound. MS (ESI+) calcd for C18H15N5O3S2 413.061631, found 413.062971.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-b47392be513742ef851ba240be3188a9
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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