5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-sulfonyl Chloride → HCID 178432588, compound

HRID 589694Notes

Reaction equation

HRID 589694 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:11][C:10]([S:12](Cl)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:6]=1.[NH:16]1[C:20]([C:21]2[CH:22]=[C:23]([NH2:27])[CH:24]=[CH:25][CH:26]=2)=[N:19][N:18]=[N:17]1>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:11][C:10]([S:12]([NH:27][C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([C:20]4[NH:19][N:18]=[N:17][N:16]=4)[CH:22]=3)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:6]=1

Participants

3

Reactant 2

HCID 27369795-(2-methyl-1,3-thiazol-4-yl)thiophene-2-sulfonyl ChlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178432588HCID 178432588, compoundYield 26%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-(2-methylthiazol-4-yl)thiophene-2-sulphonylchloride (15 mg, 0.055 mmol) and [3-(1H-tetrazol-5-yl)phenyl]amine (8 mg, 0.05 mmol) giving 5.2 mg (26%) of the title compound. MS (ESI+) calcd for C15H12N6O2S3 404.0184, found 404.0182.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-1b02cffc45d14767a1c94b8aa39af1ac
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

Loading…