2-Chlorophenylboronic acid → HCID 178527481, compound

HRID 589695Notes

Reaction equation

HRID 589695 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O>>[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 178527479HCID 178527479, compound2×

Product 1

HCID 178527481HCID 178527481, compoundYield 16.8%

Procedure

The product was prepared according to General Procedure 3, described in Example 22, starting from 5-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide (Intermediate 17) (19 mg, 0.05 mmol) and 2-chlorophenylboronic acid (9 mg, 0.06 mmol) giving 3.5 mg (16%) of the title compound. MS (ESI+) calcd for C17H12ClN5O2S2 417.012094, found 417.012204.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-492a3cedd210415a8d437369a9ed1ef8
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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