5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 178431999, compound

HRID 589701Notes

Reaction equation

HRID 589701 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10](Cl)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:12])=[O:11])=[C:7]([CH3:14])[C:6]=2[CH:15]=1

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178431999HCID 178431999, compoundYield 40%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-chloro-3-methyl-benzothiophene-2-sulfonyl chloride (15 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8 mg, 0.05 mmol) giving 8 mg (40%) of the title product. MS (ESI+) calcd for C16H12ClN5O2S2 405.012094, found 405.012744.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-b42ee1609ecf48888dfd0f893f43859a
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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