Acetic Acid → HCID 56941311, compound

Participants

Reaction Steps

The ethyl 3-{[(3-methyl-5-pyrrolidin-1-yl-1-benzothiophen-2-yl)sulfonyl]amino}benzoate (4.7 mg, 0.01 mmol) was hydrolyzed with LiOH (2.6 mg, 0.06 mmol) in THF/water (1:1, 2 mL) at 55° C. over night. The reaction mixture was neutralized with acetic acid (3.6 μL) and the mixture was concentrated. The crude product was purified by preparative HPLC (ACE C8, 5 μm 21×50 mm, flow 25 ml/min, 50 mM NH4OAc in water/CH3CN) to give 2.7 mg (6% over two steps) of the title compound. MS (ESI+) calcd for C20H20N2O4S2 416.086449, found 416.086649.

Provenance & Evidence