Lithium Hexamethyldisilazide → HCID 66799791, compound

Participants

Reaction Steps

The intermediate ethyl 3-{[(5-amino-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoate was prepared from ethyl 3-{[(5-bromo-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoate (Intermediate 18) (45 mg, 0.1 mmol) and LiHMDS (1M in THF, 120 μL, 0.12 mmol) according to General Procedure 4, described in Example 45, using a modified reaction time and reaction temperature (100° C., 1500 s, microwave reactor) yielding 7.3 mg of ethyl 3-{[(5-amino-3-methyl-1-benzothien-2-yl)sulfonyl]-amino}benzoate.

Provenance & Evidence