3-(4-methylphenyl)benzenesulfonyl Chloride → HCID 178423756, compound

HRID 589721Notes

Reaction equation

HRID 589721 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]([C:25]2[NH:29][N:28]=[N:27][N:26]=2)[CH:22]=[CH:23][CH:24]=1>>[C:2]1([CH3:1])[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([S:14]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]4[NH:29][N:28]=[N:27][N:26]=4)[CH:20]=3)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 45241733-(4-methylphenyl)benzenesulfonyl ChlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178423756HCID 178423756, compoundYield 93.5%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from [3-(4-methylphenyl)phenyl sulfonyl chloride (14.7 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.05 mmol) yielding 18.3 mg (19%) of the title compound. MS (ESI+) calcd for C20H17N5O2S 391.110296, found 391.110156.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-5fbcddfdcc1644688dfd3ef8ec0c3f04
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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