Acetic Acid → 3-[[3-(3,5-Dichlorophenyl)phenyl]sulfonylamino]benzoic acid

Participants

Reaction Conditions

Reaction Steps

The intermediate methyl 3-{[(3′,5′-dichlorobiphenyl-3-yl)sulfonyl]amino}benzoate was synthesised according to the first step in General Procedure 2, described in Example 5, with methyl 3-aminobenzoate (7.55 mg, 0.05 mmol) and [3-(3,5-dichlorophenyl)phenyl]sulfonyl chloride (17.7 mg, 0.055 mmol). The ester intermediate was dissolved in aqueous THF (2 mL, 1:1 THF/water) and then LiOH (11 mg, 0.26 mmol, 6 equiv.) was added. The reaction mixture was stirred at 56° C. overnight. After addition of HOAc (15 the solvents were evaporated giving the title compound in a mixture with LiOAc. MS (ESI+) calcd for C19H13Cl2NO4S 420.994234, found 420.994364.

Provenance & Evidence