4-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride → HCID 178527477, compound

HRID 589726Notes

Reaction equation

HRID 589726 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]3[NH:27][N:26]=[N:25][N:24]=3)[CH:18]=2)(=[O:10])=[O:9])=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1

Participants

3

Reactant 2

HCID 27786084-Bromo-2-(trifluoromethyl)benzenesulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527477HCID 178527477, compoundYield 25%

Procedure

The product was synthesized according to General Procedure 1, described in Example 1, starting with 4-bromo-2-(trifluoromethyl)benzene sulfonyl chloride (17.8 mg, 0.055 mmol) and 5-(3-amino-phenyl)tetrazole (8 mg, 0.05 mmol) yielding 5.6 mg (25%) of the title compound. MS (ESI+) calcd for C14H9BrF3N5O2S 446.961242, found 446.961472.

Workup

  1. customThe product was synthesized

Sources & evidence

ORD record
ord-4f426b447f774120ab5afd32e91fd10b
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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