4-Bromo-2-fluorobenzene-1-sulfonyl chloride → HCID 178527478, compound

HRID 589727Notes

Reaction equation

HRID 589727 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1.[NH2:13][C:14]1[CH:15]=[C:16]([C:20]2[NH:24][N:23]=[N:22][N:21]=2)[CH:17]=[CH:18][CH:19]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[NH:24][N:23]=[N:22][N:21]=3)[CH:15]=2)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1

Participants

3

Reactant 2

HCID 27363104-Bromo-2-fluorobenzene-1-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527478HCID 178527478, compoundYield 52.2%

Procedure

The product was synthesized according to General Procedure 1, described in Example 1, starting with 4-bromo-2-fluorobenzene sulfonyl chloride (17.8 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8 mg, 0.05 mmol) affording 10.4 mg (52%) of the title compound. MS (ESI+) calcd for C13H9BrFN5O2S 396.964436, found 396.963956.

Workup

  1. customThe product was synthesized

Sources & evidence

ORD record
ord-fd9b12ed5e8b4e3a9f69e92d878355d7
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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