5-(5-chloro-1,2,4-thiadiazol-3-yl)thiophene-2-sulfonyl Chloride → HCID 178527496, compound

HRID 589729Notes

Reaction equation

HRID 589729 reaction equation
[Cl:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[S:11][C:10]([S:12](Cl)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[Cl:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[S:11][C:10]([S:12]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 27358205-(5-chloro-1,2,4-thiadiazol-3-yl)thiophene-2-sulfonyl ChlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527496HCID 178527496, compoundYield 68.1%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting with 5-(5-chloro-1,2,4-thiadiazol-3-yl)thiophene-2-sulfonyl chloride (16.6 mg, 0.055 mmol) and 5-(3-amino-phenyl)tetrazole (8 mg, 0.05 mmol) affording 14.5 mg (68%) of the title compound. MS (ESI+) calcd for C13H8ClN7O2S3 424.959012, found 424.959022.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-cced908031be4c3f9eb0d471d96040ed
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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