1-Benzofuran-2-sulfonyl chloride → HCID 178527474, compound

HRID 589733Notes

Reaction equation

HRID 589733 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[S:10](Cl)(=[O:12])=[O:11].[NH2:14][C:15]1[CH:16]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:18]=[CH:19][CH:20]=1>>[NH:25]1[C:21]([C:17]2[CH:16]=[C:15]([NH:14][S:10]([C:2]3[O:1][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[CH:3]=3)(=[O:12])=[O:11])[CH:20]=[CH:19][CH:18]=2)=[N:22][N:23]=[N:24]1

Participants

3

Reactant 2

HCID 27951721-Benzofuran-2-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527474HCID 178527474, compoundYield 46%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting with 1-benzofuran-2-sulfonyl chloride (11.9 mg, 0.055 mmol) and 5-(3-amino-phenyl)-tetrazole (8 mg, 0.05 mmol) affording 7.8 mg (46%) of the title compound. MS (ESI+) calcd for C15H11N5O3S 341.058260, found 341.058160.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-bf268ceb6bf84fe6b6fc7173578c221a
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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