Trifluoroacetic acid → HCID 178527493, compound

HRID 589734Notes

Reaction equation

HRID 589734 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:10][C:9]([S:11](Cl)(=[O:13])=[O:12])=[CH:8][CH:7]=2)=[N:2]1.[NH2:15][C:16]1[CH:17]=[C:18]([C:22]2[NH:26][N:25]=[N:24][N:23]=2)[CH:19]=[CH:20][CH:21]=1.C(O)(C(F)(F)F)=O>O>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:10][C:9]([S:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]4[NH:26][N:25]=[N:24][N:23]=4)[CH:17]=3)(=[O:13])=[O:12])=[CH:8][CH:7]=2)=[N:2]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 27971805-(Isoxazol-3-yl)thiophene-2-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527493HCID 178527493, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product was prepared according to General Procedure 1, described in Example 1, with 5-isoxazol-3-ylthiophene-2-sulfonyl chloride (13.7 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol) and with a slightly modified purification method using 0.1% TFA in water as buffet. The title compound was obtained in 54% yield (11.1 mg). MS (ESI+) calcd mass for C14H10N6O3S2 374.025580, found 374.025400.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-22b160f8381945769da26cac45653170
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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