4-(1,3-Oxazol-5-yl)benzenesulphonyl chloride → HCID 178527494, compound

HRID 589752Notes

Reaction equation

HRID 589752 reaction equation
[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[O:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([S:12]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:14])=[O:13])=[CH:8][CH:7]=2)=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 27764154-(1,3-Oxazol-5-yl)benzenesulphonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527494HCID 178527494, compoundYield 23%

Procedure

The product was prepared according to General Procedure 6, described in Example 65, with 4-(1,3-oxazol-5-yl)benzenesulfonyl chloride (17.2 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol). The title compound was obtained in 23% yield (4.2 mg). MS (ESI+) calcd mass for C16H12N6O3S 368.069159, found 368.069509.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-71bd60c61c05461ebf3dec30b71ee097
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

Loading…