3',4'-Dichloro[1,1'-biphenyl]-4-sulfonyl chloride → HCID 178527486, compound

HRID 589755Notes

Reaction equation

HRID 589755 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:19][C:20]1[CH:21]=[C:22]([C:26]2[NH:30][N:29]=[N:28][N:27]=2)[CH:23]=[CH:24][CH:25]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]4[NH:30][N:29]=[N:28][N:27]=4)[CH:21]=3)(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 27947513',4'-Dichloro[1,1'-biphenyl]-4-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527486HCID 178527486, compoundYield 18%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, with 3′,4′-dichloro[1,1′-biphenyl]-4-sulfonyl chloride (17.7 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol). The title compound was obtained in 18% yield (4.1 mg). MS (ESI+) calcd mass for C19H13Cl2N5O2S 445.016701, found 445.016581.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-d33cdec5b11b483fbd7d413dd2087190
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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