5-isoxazol-5-ylthiophene-2-sulfonyl chloride → HCID 178527492, compound

HRID 589756Notes

Reaction equation

HRID 589756 reaction equation
[O:1]1[C:5]([C:6]2[S:10][C:9]([S:11](Cl)(=[O:13])=[O:12])=[CH:8][CH:7]=2)=[CH:4][CH:3]=[N:2]1.[NH2:15][C:16]1[CH:17]=[C:18]([C:22]2[NH:26][N:25]=[N:24][N:23]=2)[CH:19]=[CH:20][CH:21]=1>>[O:1]1[C:5]([C:6]2[S:10][C:9]([S:11]([NH:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]4[NH:26][N:25]=[N:24][N:23]=4)[CH:17]=3)(=[O:13])=[O:12])=[CH:8][CH:7]=2)=[CH:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 27953305-isoxazol-5-ylthiophene-2-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527492HCID 178527492, compound

Procedure

The title compound was prepared according to General Procedure 1, described in Example 1, with 5-isoxazol-5-ylthiophene-2-sulfonyl chloride (13.7 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol). MS (ESI+) calcd mass for C14H10N6O3S2 374.025580, found 374.025420.

Sources & evidence

ORD record
ord-dfe7de8264204e60b829b830dc5e6c82
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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