(3-Methoxyphenyl)boronic acid → HCID 178489712, compound

HRID 589761Notes

Reaction equation

HRID 589761 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[CH3:22][O:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1>>[CH3:22][O:23][C:24]1[CH:29]=[C:28]([C:2]2[S:6][C:5]([S:7]([NH:10][C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]4[NH:21][N:20]=[N:19][N:18]=4)[CH:12]=3)(=[O:9])=[O:8])=[CH:4][CH:3]=2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 178527479HCID 178527479, compound2×

Product 1

HCID 178489712HCID 178489712, compound

Procedure

The title compound was prepared according to General Procedure 3, described in Example 22, using 5-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide (Intermediate 17) (19 mg, 0.055 mmol) and 3-methoxyphenylboronic acid (9 mg, 0.06 mmol). MS (ESI+) calcd mass for C18H15N5O3S2 413.061631, found 413.062021.

Sources & evidence

ORD record
ord-deb5b70428444a708dfe4020bc7c9e04
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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