反应详情

The product was prepared from 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoic acid (21 mg, 0.055 mmol) (Intermediate 19) and 2-methoxyethanol (7.6 mg, 0.100 mmol) according to the General Procedure 7, described in Example 107. The title compound was obtained in 70% yield (16.9 mg). 1H NMR (500 MHz, CDCl3) δ ppm 2.47 (s, 3 H) 3.40 (s, 3 H) 3.67-3.70 (m, 2 H) 4.42-4.45 (m, 2 H) 6.92 (s, 1 H) 7.37 (dd, J=8.02, 7.74 Hz, 1 H) 7.45 (dd, J=8.73, 1.96 Hz, 1 H) 7.45 (ddd, J=8.02, 2.34, 1.17 Hz, 1 H) 7.72 (dd, J=8.73, 0.60 Hz, 1 H) 7.72 (dd, J=1.96, 0.60 Hz, 1 H) 7.74 (dd, J=2.34, 1.59 Hz, 1 H) 7.87 (ddd, J=7.74, 1.59, 1.17 Hz, 1 H). MS (ESI+) m/z 440 [M+H]+.