1-Butanol → Butyl 3-{[(5-chloro-3-methyl-1-benzothiophen-2-yl)sulfonyl]amino}benzoate

Participants

Reaction Steps

The product was prepared from 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoic acid (21 mg, 0.055 mmol) (Intermediate 19) and 1-butanol (7.4 mg, 0.100 mmol) according to the General Procedure 7, described in Example 107. The title compound was obtained in 77% yield (18.5 mg). 1H NMR (500 MHz, CDCl3) δ ppm 0.95 (t, J=7.39 Hz, 3 H) 1.37-1.46 (m, 2 H) 1.65-1.72 (m, 2 H) 2.44 (s, 3 H) 4.27 (t, J=6.65 Hz, 2H) 6.88 (s, 1 H) 7.36 (dd, J=8.06, 7.67 Hz, 1 H) 7.42 (ddd, J=8.06, 2.32, 1.22 Hz, 1 H) 7.45 (dd, J=8.67, 1.95 Hz, 1 H) 7.71 (dd, J=8.67, 0.52 Hz, 1 H) 7.70-7.71 (m, 1 H) 7.71 (dd, J=1.95, 0.52 Hz, 1 H) 7.84 (ddd, J=7.67, 1.50, 1.21 Hz, 1 H). MS (ESI+) m/z 438 [M+H]+.

Provenance & Evidence