1-Propanol → Propyl 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoate

Participants

Reaction Steps

The product was prepared from 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoic acid (21 mg, 0.055 mmol) (Intermediate 19) and 1-propanol (6.0 mg, 0.100 mmol) according to the General Procedure 7, described in Example 107. The title compound was obtained in 75% yield (17.6 mg). 1H NMR (500 MHz, CDCl3) δ ppm 0.97 (t, J=7.45 Hz, 3 H) 1.68-1.77 (m, 2 H) 2.44 (s, 3 H) 4.23 (t, J=6.65 Hz, 2 H) 6.90 (s, 1 H) 7.36 (dd, J=8.05, 7.70 Hz, 1 H) 7.42 (ddd, J=8.05, 2.34, 1.22 Hz, 1 H) 7.44 (dd, J=8.73, 1.95 Hz, 1H) 7.71 (dd, J=8.73, 0.60 Hz, 1 H) 7.71 (dd, J=1.95, 0.60 Hz, 1 H) 7.71 (dd, J=2.34, 1.53 Hz, 1 H) 7.84 (ddd, J=7.70, 1.53, 1.22 Hz, 1 H). MS (ESI+) m/z 424 [M+H]+.

Provenance & Evidence