Phenol → HCID 66799888, compound

Participants

Reaction Steps

The product was prepared from 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoic acid (21 mg, 0.055 mmol) (Intermediate 19) and phenol (9.4 mg, 0.100 mmol) according to the General Procedure 7, described in Example 107. The title compound was obtained in 74% yield (18.7 mg). 1H NMR (500 MHz, CDCl3) δ ppm 2.50 (s, 3 H) 7.06 (s, 1 H) 7.10-7.15 (m, 2 H) 7.25-7.29 (m, 1 H) 7.39-7.44 (m, 2 H) 7.44 (dd, J=8.10, 7.70 Hz, 1 H) 7.44 (dd, J=8.65, 2.02 Hz, 1 H) 7.51 (ddd, J=8.10, 2.34, 1.15 Hz, 1 H) 7.72 (dd, J=8.65, 0.57 Hz, 1 H) 7.73 (dd, J=2.02, 0.57 Hz, 1 H) 7.86 (dd, J=2.34, 1.58 Hz, 1H) 7.99 (ddd, J=7.70, 1.58, 1.15 Hz, 1 H). MS (ESI+) m/z 458 [M+H]+.

Provenance & Evidence