Ethyl 2-amino-4-methylthiazole-5-carboxylate → HCID 86689194, compound

Participants

Reaction Steps

The product was prepared from ethyl 2-amino-4-methyl-1,3-thiazole-5-carboxylate (9 mg, 0.050 mmol) and 5-chloro-3-methylbenzothiophene-2-sulfonyl chloride (14 mg, 0.050 mmol) according to the General Procedure 9, described in Example 123, using a slightly modified reaction temperature of 60° C. and a reaction time of one week. The title compound was obtained in 18% yield (3.9 mg). 1H NMR (500 MHz, CDCl3) δ ppm 1.34 (t, J=7.15 Hz, 3 H) 2.60 (s, 3 H) 2.61 (s, 3 H) 4.30 (q, J=7.15 Hz, 2 H) 7.42 (dd, J=8.63, 2.01 Hz, 1 H) 7.66 (dd, J=8.63, 0.50 Hz, 1 H) 7.70 (dd, J=2.01, 0.50 Hz, 1 H). MS (ESI+) m/z 431 [M+H]+.

Provenance & Evidence