Ethyl 2-amino-4-methylthiazole-5-carboxylate → 2-({[5-Chloro-4-(2,5-difluorophenyl)thiophen-2-yl]sulfonyl}amino)-4-methyl-1,3-thiazole-5-carboxylic acid

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Reaction Steps

The product was prepared from ethyl 2-amino-4-methylthiazole-5-carboxylate (9.3 mg, 0.050 mmol) and 5-chloro-4-(2,5-difluorophenyl)thiophene-2-sulfonyl chloride (Intermediate 20) (17 mg, 0.050 mmol) according to the General Procedure 10, described in Example 128. The title compound was obtained in 17% yield (3.9 mg). 1H NMR (500 MHz, MeOH-d4) δ ppm 2.50 (s, 3 H) 7.18-7.23 (dddd, J=9.16, 7.57, 3.91, 3.05 Hz, 1 H) 7.26 (td, J=9.16, 4.60 Hz, 1H) 7.26 (ddd, J=8.70, 5.70, 3.05 Hz, 1 H) 7.57 (d, J=1.71 Hz, 1 H). MS (ESI+) m/z 451 [M+H]+.

Provenance & Evidence