(2,3-Dihydro-1-benzofuran-5-yl)boronic acid → HCID 66799948, compound

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Reaction Steps

The product was prepared from 3-{[(4-bromo-5-chlorothiophen-2-yl)sulfonyl]amino}-2-hydroxybenzoic acid (Intermediate 22) (20.6 mg, 0.050 mmol) and 2,3-dihydrobenzofuran-5-boronic acid (9 mg, 0.055 mmol) according to the General Procedure 12, described in Example 135. The title compound was obtained in 46% yield (10.6 mg). 1H NMR (500 MHz, MeOH-d4) δ ppm 3.23 (t, J=8.70 Hz, 2 H) 4.58 (t, J=8.70 Hz, 2 H) 6.76 (d, J=8.24 Hz, 1 H) 6.90 (t, J=7.95 Hz, 1 H) 7.14-7.17 (ddt, J=8.24, 1.97, 0.71 Hz, 1 H) 7.25 (dt, J=1.97, 1.30 Hz, 1 H) 7.31 (s, 1 H) 7.66 (dd, J=7.95, 1.65 Hz, 1 H) 7.74 (dd, J=7.95, 1.65 Hz, 1 H). MS (ESI+) m/z 452 [M+H]+.

Provenance & Evidence