2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 66800076, compound

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Reaction Steps

The product was prepared from 3-{[(4-bromo-5-chlorothiophen-2-yl)sulfonyl]amino}-2-hydroxybenzoic acid (Intermediate 22) (20.6 mg, 0.050 mmol) and 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (11 μl, 0.055 mmol) according to the General Procedure 12, described in Example 135. The title compound was obtained in 24% yield (5.3 mg). 1H NMR (500 MHz, MeOH-d4) δ ppm 6.85 (ddd, J=7.60, 7.32, 1.15 Hz, 1 H) 6.87 (ddd, J=8.21, 1.15, 0.45 Hz, 1 H) 6.88 (t, J=7.95 Hz, 1 H) 7.15 (ddd, J=7.60, 1.71, 0.45 Hz, 1 H) 7.20 (ddd, J=8.21, 7.32, 1.71 Hz, 1 H) 7.39 (s, 1 H) 7.65 (dd, J=7.95, 1.65 Hz, 1 H) 7.71 (dd, J=7.95, 1.65 Hz, 1 H). MS (ESI+) m/z 426 [M+H]+.

Provenance & Evidence