Hydrochloric Acid → cis-(1S,2S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;hydrochloride

Participants

Reaction Conditions

Reaction Steps

Ticagrelor (0.5 g) and ethyl acetate (15 mL) were charged into a round bottom flask and the mixture was stirred at about 25-30° C. for about 15 minutes for clear solution. Then aqueous hydrochloric acid (0.12 mL, 35%) was added to the above reaction mixture at 25-35° C. and stirred for solid separation for about 2 hours. The solid was filtered, washed with ethyl acetate (5 mL) and dried to afford the title compound in about 75% yield having chiral HPLC purity of 99.55%.

Provenance & Evidence