反应详情

温度

30 °C

Ticagrelor (0.5 g) and acetone (10 mL) were charged into a round bottom flask and the mixture was stirred at about 30° C. for about 15 minutes for clear solution. Then D (−)-tartaric acid (0.16 g) was added to the above reaction mixture at about 30° C. and mixture was stirred for overnight. To the clear solution, n-hexane (35 mL) was added and stirred for about 1 hour at 25-30° C. for solid separation. The solid was filtered, washed with n-hexane (5 mL) and dried to afford the title compound in about 93% yield having chiral HPLC purity of about 98%.

1. stirringmixture was stirred for overnight
2. stirringstirred for about 1 hour at 25-30° C. for solid separation
3. filtrationThe solid was filtered
4. washwashed with n-hexane (5 mL)
5. customdried