Sodium Hydroxide → HCID 86680814, compound

HRID 589873Notes

Reaction equation

HRID 589873 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH:7]2[C:19]([O:21]C)=[O:20])=[O:5])[CH2:3][CH2:2]1.[OH-].[Na+:24]>CO.O>[CH:1]1([C:4]([N:6]2[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:16])[CH3:17])=[O:13])[CH2:8][CH:7]2[C:19]([O-:21])=[O:20])=[O:5])[CH2:3][CH2:2]1.[Na+:24]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 66585107HCID 66585107, compound

Product 1

HCID 86680814HCID 86680814, compoundYield 106.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 11.5 g (36.8 mmol) of 1-tert-butyl 3-methyl 4-cyclopropanecarbonylpiperazine-1,3-dicarboxylate in 127.5 ml of methanol are added 1.77 g of sodium hydroxide dissolved in 22.5 ml of water. The mixture is stirred for 24 hours and the reaction medium is then concentrated under reduced pressure and the residue co-evaporated with toluene, to give 12.6 g of sodium 1-tert-butyl 4-cyclopropanecarbonylpiperazine-1,3-dicarboxylate in the form of a white powder after drying, and is used as obtained in the rest of the synthesis.

Workup

  1. concentrationthe reaction medium is then concentrated under reduced pressure

Sources & evidence

ORD record
ord-6ffe711fe0b242e19c2d05f1f74bd664
Source dataset
uspto-grants-2016_01
Patent number
US09233965B2

Reaction notes

Loading…