Chlorotrimethylsilane → HCID 86680817, compound

HRID 589875Notes

Reaction equation

HRID 589875 reaction equation
[Br:1][C:2]1[C:3](C(=O)N)=[C:4]2[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6][N:5]2[C:17]=1[CH:18]1[CH2:20][CH2:19]1.C[Si]([Cl:28])(C)C>CO>[ClH:28].[Br:1][C:2]1[CH:3]=[C:4]2[CH:9]=[N:8][CH2:7][CH2:6][N:5]2[C:17]=1[CH:18]1[CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 66585102HCID 66585102, compound

Product 1

HCID 86680817HCID 86680817, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution under nitrogen of 6.34 g (16.5 mmol) of tert-butyl 7-bromo-8-carbamoyl-6-cyclopropyl-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylate in 120 ml of methanol are added 10.5 ml of trimethylsilyl chloride. After reaction for 18 hours, the medium is concentrated under reduced pressure, the residue is taken up in toluene and the solvent is evaporated off under reduced pressure. 5.4 g of 7-bromo-6-cyclopropyl-3,4-dihydropyrrolo[1,2-a]pyrazine hydrochloride are thus obtained in the form of a yellow powder.

Workup

  1. customAfter reaction for 18 hours
  2. concentrationthe medium is concentrated under reduced pressure
  3. customthe solvent is evaporated off under reduced pressure

Sources & evidence

ORD record
ord-ea6836cb1b01440a95fd97feb25e97b6
Source dataset
uspto-grants-2016_01
Patent number
US09233965B2

Reaction notes

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