Ammonia → HCID 66585058, compound

Participants

Reaction Conditions

Reaction Steps

To 1.79 g (3.66 mmol) of tert-butyl 6-bromo-7-(3-fluorophenyl)-8-(1H-imidazol-1-ylcarbonyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate in an autoclave are added 30 ml of 33% aqueous ammonia. The mixture is stirred for 5 hours 30 minutes at 90° C. and, after cooling, is then poured into water, to give 1.26 g of tert-butyl 8-carbamoyl-6-bromo-7-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate after drying over potassium hydroxide.

Provenance & Evidence