m-Tolyl isocyanate → 1-[4-(Imidazo[1,2-b]pyridazin-6-ylethynyl)phenyl]-3-(3-methylphenyl)urea

Participants

Reaction Steps

A reaction mixture of 4-(imidazo[1,2-b]pyridazin-6-ylethynyl)aniline (93.6 mg, 0.4 mmol, 1 eq) and m-tolyl isocyanate (0.051 mL, 1 eq) in anhydrous THF (4 mL) was stirred at room temperature for four hours. It was then diluted with water and a solid which precipitated was filtered. The solid was further triturated with ethyl acetate and 1-[4-(imidazo[1,2-b]pyridazin-6-ylethynyl)phenyl]-3-(3-methylphenyl)urea was obtained as a yellow solid upon filtration in amount of 125 mg.

Provenance & Evidence