HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanate → 1-{4-[(2-Aminoimidazo[1,2-b]pyridazin-6-yl)ethynyl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | 2-Fluoro-5-(trifluoromethyl)phenyl isocyanate | HCID 2733380 | — |
| Reactant | 6-[(4-Aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine | HCID 118638446 | — |
| Product | 1-{4-[(2-Aminoimidazo[1,2-b]pyridazin-6-yl)ethynyl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea | HCID 118638411 | — |
Reaction Steps
The compound of Example 4 was made by preparing 6-[(4-aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine as in Example 20, followed by a procedure similar to Example 3 using 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene as the isocyanate (see also Schemes 1, 2, and 9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233968B1 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-5b0b3f138f8040f286ca27b4a791c406 |
| Source note | uspto-grants-2016_01 |